John J. Piwinski, PhD Selected Publications

F. Bennett, H. S. Kezar III, V. Girijavallabhan, Y. Huang, R. Huelgas, R. Rossman, N.-Y. Shih, J. J. Piwinski, M. MacCoss, C. D. Kwong, J. L. Clark, A. T. Fowler, F. Geng, A. Roychowdhury, R. C. Reynolds, J. A. Maddry, S. Ananthan, J. A. Secrist III, C. Li, R. Chase, S. Curry, H.-C. Huang, X. Tong, F. G. Njoroge, A. Arasappan: Pyridofuran Substituted Pyrimidine Derivatives as HCV Replication (Replicase) Inhibitors. Bioorg. Med. Chem. Lett. 22: 5144, 2012.

R. Kuang, H.-J. Shue, L. Xiao, D. Blythin, N.-Y. Shih, X. Chen, D. Gu, J. Schwerdt, L. Lin, P. C. Ting, J. Cao, R. Aslanian, J. J. Piwinski, D. Prelusky, P. Wu, J. Zhang, X. Zhang, C. S. Celly, M. Billah, P. Wang: Discovery of Oxazole-Based PDE-4 Inhibitors with Picomolar Potency. Bioorg. Med. Chem. Lett. 22: 2594, 2012.

Arasappan, F. Bennett, S. L. Bogen, S. Venkatraman, M. Blackman, K. Chen, S. Hendrata, Y. Huang, R. M. Huelgas, L. Nair, A. I. Padilla, W. Pan, R. Pike, P. Pinto, S. Ruan, M. Sannigrahi, F. Velazquez, B. Vibulbhan, W. Wu, W. Yang, A. K. Saksena, V, Girijavallabhan, N.-Y. Shih, J. Kong, T. Meng, Y. Jin, J. Wong, P. McNamara, A. Prongay, V. Madison, J. J. Piwinski, K.-C. Cheng, R. Morrison, B. Malcolm, X. Tong, R. Ralston, F. G. Njoroge, “Discovery of Narlaprevir (Sch 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor. ACS Med. Chem. Lett. 1: 64, 2010.

W. Yu, Z. Guo, P. Orth, V. Madison, L. Chen, C. Dai, R. J. Feltz, V. M. Girijavallabhan, S. H. Kim, J. A. Kozlowski, B. J. Lavey, D. Li, D. J. Lundell, X. Niu, J. J. Piwinski, J. Popovici-Muller, R. Rizvi, K. E. Rosner, B. B. Shankar, N. –Y. Shih, M. A. Siddiqui, J. Sun, L. Tong, S. Umland, M. K. C. Wong, D.Y. Yang, G. Zhou: Discovery and SAR of Hydantoin TACE Inhibitors. Bioorg. Med. Chem. Lett. 20: 1877, 2010.

K. E. Rosner, Z. Guo, P. Orth, G. W. Shipps, Jr., D. B. Belanger, T.-Y. Chan, P. J. Curran, C. Dai, Y. Deng, V. M. Girijavallabhan, L. Hong, B. J. Lavey, J. F. Lee, D. Li, Z. Liu, J. Popovici-Muller, P. C. Ting, H. Vaccaro, L. Wang, T. Wang, W. Yu, G. Zhou, X. Niu, J. Sun, J. A. Kozlowski, D. J. Lundell, V. Madison, B. McKittrick, J. J. Piwinski, N.-Y. Shih, M. A. Siddiqui, C. O. Strickland. The Discovery of Novel Tartrate-Based TNF-α Converting Enzyme (TACE) Inhibitors. Bioorg. Med. Chem. Lett. 20: 1189, 2010.

R. Aslanian, J. J. Piwinski, X. Zhu, T. Priestley, S. Serota, X.-Y. Du, X.-S. Zhang, R. L. McLeod, R. West, S. M. Williams, J. A. Hey: Structural Determinants for Histamine H1 Affinity, hERG Affinity and QTc Prolongation in a Series of Terfenadine Analogs. Bioorg. Med. Chem. Lett. 19: 5043, 2009.

G. Chen, I. Daaro, B. N. Pramanik, J. J. Piwinski: Structural Characterization of In Vitro Rat Liver Microsomal Metabolites of Antihistamine Desloratadine Using LTQ-Orbitrap Hybrid Mass Spectrometer in Combination with Online Hydrogen/Deuterium Exchange HR-LC/MS. J. Mass Spectrum 44: 203, 2009.

F. G. Njoroge, K. X. Chen, N.-Y. Shih, J. J. Piwinski: Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection. Accts. Chem. Res. 41: 50, 2008.

S. Venkatraman, S. L. Bogen, A. Arasappan, F. Bennett, K. Chen, E. Jao, Y-T. Liu, R. Lovey, S. Hendrata, Y. Huang, W. Pan, T. Parekh, P. Pinto, V. Popov, R. Pike, S. Ruan, B. Santhanam, B. Vibulbhan, W. Wu, W. Yang, J. Kong, X. Liang, J. Wong, R. Liu, N. Butkiewicz, R. Chase, A. Hart, S. Agrawal, P. Ingravallo, J. Pichardo, R. Kong, B. Baroudy, B. Malcolm, Z. Guo, A. Prongay, V. Madison, L. Broske, X. Cui, K-C. Cheng, Y. Hsieh, J-M. Brisson, D. Prelusky, W. Korfmacher, R. White, S. Bogdanowich-Knipp, A. Pavlovsky, P. Bradley, A. K. Saksena, A. Ganguly, J. J. Piwinski, V, Girijavallabhan, F. G. Njoroge: Discovery of (1R,5S)-N-(3-Amino-1-[cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl) amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034), a Selective, Potent, Orally Bioavailable Hepatitis C Virus NS3 Protease Inhibitor: A Potential Therapeutic Agent for the Treatment of Hepatitis C Infection. J. Med. Chem. 49: 6074, 2006.

C. L. Strickland, P. C. Weber, W. T. Windsor, Z. Wu, H. V. Le, M. M. Albanese, C. S. Alvarez, D. Cesarz, J del Rosario, J. Deskus, A. K. Mallams, F. G. Njoroge, J. J. Piwinski, S. Remiszewski, R. R. Rossman, A. G. Taveras, B. Vibulbhan, R. J. Doll, V. Girijavallabhan and A. K. Ganguly: Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Colorimetric Studies of Structure-Activity Relationships. J. Med. Chem., 42, 2125, 1999.